Tumor Virology

Tumor virology deals with the specific virus infections and cancer, oncogenes, tumor suppressors, oncogenic cofactors, disruption of innate/ adaptive immune responses, latency, viral mimicry/piracy of cellular regulatory genes, genomic instability and role of non-coding RNAs in viral pathogenesis. The purpose of this study is to develop viral vectors for human cancer gene therapy and to progress vaccine strategies for treatment of viral-associated cancers. Several methods are being trailed including genetic immunization with recombinant viral vectors based on Semliki Forest virus, immune checkpoint inhibitors and strategies to re-modulate the immunosuppressive tumor environment