It is the system of antigenic system material is used to arouse an individual immune system to prevent the pathogens. Vaccines are the preventive measures of infectious diseases. The Influence of the vaccines is been promoted worldwide. This is one of the methods of preventing infectious diseases more effectively. By using, vaccination method we have prevented many diseases, such as smallpox. The vaccine for smallpox was discovered by the Louis pasture. Through this lead of vaccine, we have eradicated smallpox by 1979. In cancer, the tumour antigen led a path towards antigen-specific immunotherapy of cancer. Today antitumor vaccination hasn't reached its promised destination. This happens because the failure includes a tumour immune escape mechanism, limitations in the availability of tumour-specific antigens in the destination immunological context.